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Natural History Study “Pathway to Prevention”

The Pathway to Prevention study offers a blood test that can identify the risk for type 1 diabetes up to 10 years before symptoms actually appear. Since inception, TrialNet has screened over 159,000 participants in this study. Of these, the University of Florida TrialNet research team, has screened over 4,000 participants, and, the UF TrialNet Clinical Center region has screened close to 12,000 participants.

Study Name: TrialNet Natural History Study2013 WDD Blue Photo Contest Finalist

Principal Investigator: Desmond Schatz, MD

Study Coordinator: Jennifer Hosford, MPH

Recruitment Coordinator: Annie Abraham

Phone: 352-294-5762 or 352-294-5759

Email: or


What is the TrialNet Natural History Study?

TrialNet is screening relatives of people with type 1 diabetes to find out if these family members are at risk for developing diabetes. Relatives of people with type 1 diabetes have about a 5 percent chance of testing positive for autoantibodies associated with diabetes. If you learn you are at risk for developing type 1 diabetes, additional test will be offered to estimate your chances of developing type 1 diabetes. If you qualify,you may have an opportunity to be enrolled in either a Natural History or Prevention Study. All research volunteers will be closely monitored for early detection of type 1 diabetes. Early detection of type 1 diabetes may improve your blood sugar control and reduce your chances of developing complications. You will be part of a research program that may help other people at risk for Type 1 diabetes.

Who can participate?

  • Individuals who are 1-45 years of age with a parent, child, brother, or sister with Type 1 diabetes
  • Individuals who are 1-20 years of age with a niece, nephew, aunt, uncle, grandparent, half-sibling or cousin with Type 1 diabetes.
  • Note: A relative diagnosed before the age of 40 AND started on insulin within the first year of diagnosis probably has Type 1 diabetes.

What will study participants be asked to do?

Screening involves a simple blood test for the presence of diabetes-related autoantibodies that may appear years before type 1 diabetes develops. TrialNet has established screening sites throughout North America. Please contact us to find a screening location near you, or to a request a test kit, call 877-343-2377.

Informed Consent Form available upon request